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Hyaluronidase: What You Need to Know About Dissolving Fillers

Hyaluronidase: What You Need to Know About Dissolving Fillers

Cosmetic fillers have gained immense popularity in recent years, offering individuals a way to enhance their natural beauty and address signs of aging. One of the most commonly used fillers is hyaluronic acid (HA), a naturally occurring substance in the body that provides hydration, volume, and structure to the skin. While fillers can provide fantastic results, there are instances where patients may seek to dissolve or remove the filler due to various reasons. This is where hyaluronidase comes into play. In this article, we will explore hyaluronidase and everything you need to know about dissolving fillers.

What is Hyaluronidase?

Hyaluronidase is an enzyme that breaks down hyaluronic acid, the primary component of many dermal fillers. It is naturally produced by the body and plays a crucial role in tissue remodeling and wound healing. Hyaluronic acid fillers create volume and structure by binding to water molecules in the skin, providing a plumping effect. However, there are situations where the filler may not have the desired outcome or complications arise, leading patients to seek a solution. Hyaluronidase offers a safe and effective way to dissolve hyaluronic acid fillers, allowing for adjustments, corrections, or complete removal.

How Does Hyaluronidase Work?

Hyaluronidase works by breaking down the bonds between the hyaluronic acid molecules, allowing the body's natural processes to eliminate the filler more quickly. When injected into the treatment area, hyaluronidase spreads through the tissue and begins to degrade the hyaluronic acid, effectively dissolving the filler. This process accelerates the breakdown and absorption of the filler, enabling the skin to return to its pre-treatment state or preparing it for alternative treatments.

When is Hyaluronidase Used?

Hyaluronidase is primarily used in cases where patients are dissatisfied with the results of their dermal filler treatment, experience complications, or require corrections. Common situations that may necessitate the use of hyaluronidase include:

Overfilling or uneven distribution: Occasionally, patients may receive more filler than desired or experience uneven distribution, resulting in an unnatural appearance. Hyaluronidase can help adjust and balance the filler, providing a more harmonious result.

Vascular compromise: In rare cases, the injection of dermal fillers can inadvertently affect blood vessels, leading to compromised blood flow and potential tissue damage. This is a serious concern that requires immediate attention. Hyaluronidase can be used as an emergency treatment to dissolve the filler and restore proper blood circulation, mitigating the risk of severe complications.

Infection or inflammation: If an infection or inflammatory reaction occurs after filler treatment, hyaluronidase may be used to remove the filler and alleviate the associated symptoms. This is done to prevent further complications and promote healing.

Filler dissatisfaction: Sometimes, patients may simply be dissatisfied with the results of their filler treatment. Whether it's due to unrealistic expectations or a change of preference, hyaluronidase can be utilized to dissolve the filler, allowing for a fresh start or alternative treatment options.

Is Hyaluronidase Safe?

When administered by a qualified and experienced medical professional, hyaluronidase is generally safe. However, it is essential to keep in mind that all medical procedures carry some level of risk. Potential risks and side effects of hyaluronidase may include temporary redness, swelling, bruising, itching, and discomfort at the injection site. These are typically mild and subside on their own within a few days.

Serious complications are rare but can include allergic reactions or infection, although these are highly unlikely. It is crucial to consult with a trusted healthcare professional to determine the best course of action for your specific situation. 


Hyaluronidase is a valuable tool in the field of aesthetic medicine, offering a solution for dissolving hyaluronic acid-based fillers. Whether it's to correct overfilling, uneven distribution, complications, or simply a desire to reverse the effects of fillers, hyaluronidase can help restore a more natural appearance. However, it's important to approach any cosmetic procedure with caution and seek the expertise of a qualified medical professional. If you are considering dissolving fillers with hyaluronidase, schedule a consultation with Lumina Aesthetics Clinic to discuss your concerns and goals.

For more information contact us through +62 812 1068 8884 / +62 812 2888 8837/ +62 812-2888-8337 or email [email protected].

Lumina Aesthetics Clinic

Jl. Dewi Sri No. 88E, Legian

+62 812 1068 8884 | +62 812 2888 8837

[email protected]


Lumina Aesthetics Alam Sutera

Brooklyn Apartment, Alam Sutera, Jl. Alam Sutera Boulevard, Pakualam, Kec. Serpong, Tangerang, Banten 15320

+62 812-2888-8337

[email protected]


    Contact Information
    • [email protected]
    • +62 8122 8888 837
    • Jl. Dewi Sri No 88E Kelurahan Legian Kec. Kuta Selatan Bali 80361